cannabis

According to the Center for Disease Control and Prevention, Lyme disease is considered as the most common vector-borne disease in the US. Lyme disease is spread through a tick bite, which contains the bacteria “Borrelia burgdorferi.” 

Mostly, antibiotics are used to treat the clinical symptoms of Lyme disease. Can a mind-alerting substance be used in managing the clinical signs of Lyme disease? If so, how does it work? In this blog, we will understand how cannabis helps to ease the symptoms of Lyme disease. 

What is cannabis?

Cannabis is a plant that contains psychoactive properties, which have the potential to cause alterations in thoughts and perceptions. This plant contains different chemical compounds, such as tetrahydrocannabinol, that impact the mind. Due to its relaxing effects, this drug is used to treat glaucoma and severe pain. 

Cannabis can be used to manage a variety of conditions, such as

  • Inflammation
  • Severe pain
  • Seizures
  • Anxiety
  • Migraine

Cannabis is associated with certain effects, such as experiencing intense sounds, changes in perception of events, more focus, and creativity.

Icannabis

What are the conventional treatment approaches for Lyme disease?

Mostly, a 10-14 day course of antibiotics is prescribed for treating Lyme disease. When antibiotics are administered at an early stage, patients can almost recover completely. The length of antibiotic treatment is decided on:

  • Clinical signs
  • Presence of allergies
  • Pre-existing conditions
  • Stage of the disease

In patients with Lyme disease-related atrioventricular (AV) block, temporary cardiac pacing is indicated. In later stages of Lyme disease, antibiotics are administered intravenously. IV route helps to treat cardiovascular symptoms, meningitis, encephalitis, etc. To manage pain, non-steroidal anti-inflammatory drugs are indicated.

What are the benefits of cannabis for Lyme disease?

The endocannabinoid system (ECS) is responsible for maintaining the function of the central nervous system and immune system. Enzymes, receptors, and endocannabinoids constitute the ECS. Cannabinoids modulate the functions of the body by binding to ECS receptors. This can help in reducing clinical symptoms, such as pain, seizures, headaches, etc. 

Some of the research studies have pointed out that endocannabinoid deficiency is the major cause of conditions such as IBS, fibromyalgia, etc. Brain fog appears as a clinical manifestation of Lyme disease. Cannabis can reduce the inflammation of the brain and help in regenerating brain cells. 

Lyme disease can cause sleep disruption. Cannabis can regulate autonomic output and lead to good sleep. It can also reduce breathing disturbances during sleep. It has been estimated that around 70% of the individuals experienced better sleep with cannabis use.  

The limbic system will be overactive in individuals with Lyme disease, leading to “limbic rage syndrome.” Cannabis can influence the dopamine level by reducing the sensory input stimulation, which helps in limiting symptoms.

Cannabis can help in managing the clinical symptoms of Lyme disease due to the presence of constituents like tetrahydrocannabinol, etc. Patients with Lyme disease suffer from various conditions, such as tenderness in the joint region. Cannabis has anti-inflammatory properties that help in reducing pain and swelling. The drug can help in managing mental health conditions, such as clinical depression, anxiety, etc.

benefits

What are the best methods of taking cannabis for Lyme-related symptoms?

Patients with chronic Lyme disease find it difficult to manage the symptoms of the disease, which include joint pain, inflammation, fatigue, and sleeping disorders. Cannabis has become a choice that can be consumed through different methods. 

Patients with generalized pain, insomnia, and chronic fatigue are preferably treated with edibles and tinctures. Edibles will take a long time to digest, providing a long-lasting effect. Tinctures administered under the tongue take less time, around 15 to 45 minutes, to have an effect.

Topical cannabis is considered a useful choice when you want to treat localized pain. They are topically applied to skin and act by interacting with cannabinoid receptors to minimize the effects of pain and inflammation.

To use it safely, patients should begin with small doses and then adjust gradually. It is important to consult a healthcare specialist, especially when it comes to patients who are using antibiotics or other pharmaceuticals.

Are there any risks associated with cannabis use?

Patients using cannabis as a treatment method for Lyme disease should expect a few risks and side effects. One of the major risks associated with Lyme disease is immune suppression that affects the function of macrophages and T-cells. This may hamper the body’s ability to fight against the infection. 

Drug interaction is another possibility that may occur when taken with an analgesic or anti-inflammatory drug. This may cause changes in the level of the drugs in the body, leading to side effects.

Conclusion

  • Cannabis can help in relieving the clinical symptoms of Lyme disease by interacting with the endocannabinoid system.
  • Cannabis must be used only after consulting the doctor, as it is associated with several complications, such as suppression of the immune system, drug interactions, etc.
  • With accurate doses, cannabis can be used to improve the clinical symptoms in Lyme disease patients.

References

  1. National Institute on Drug Abuse (NIDA). Cannabis (Marijuana) [Internet]. Bethesda (MD): NIDA; 2024 Sept [cited 2025 Jun 23]. Available from: https://nida.nih.gov/research-topics/cannabis-marijuana
  2. Centers for Disease Control and Prevention. Treatment for Lyme Disease. [Internet]. Atlanta (GA): CDC; 2023 Apr [cited 2025 Jun 23]. Available from: https://www.cdc.gov/lyme/treatment/index.html
  3. Lawrence S. Cannabis, the Endocannabinoid System, and Tick‑Borne Diseases [Internet]. Global Lyme Alliance; 2025 Feb 21 [cited 2025 Jun 23]. Available from: https://www.globallymealliance.org/blog/cannabis-the-endocannabinoid-system-and-tick-borne-diseases
  4. Bruni N, Della Pepa C, Oliaro-Bosso S, Pessione E, Gastaldi D, Dosio F. Cannabinoid delivery systems for pain and inflammation treatment. Molecules [Internet]. 2018 Sep 21 [cited 2025 Jun 23];23(10):2478. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298645/

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Sophia Williams

Health & Wellness Content Strategist

Sophia Williams is a passionate content writer specializing in health and wellness and is deeply interested in chronic conditions like Lyme disease. With years of experience in creating educational and empathetic content, I aim to raise awareness and provide valuable insights that empower readers to take charge of their health.